DEPRESSION RESEARCH
$1,114,797 awarded to research since 1985
19 million American adults live with major depression. Once thought of as simply “feeling blue,” it is now better understood that the word “depression” describes a family of very real mood disorders. While the symptoms and contexts of these illnesses vary, they can include prolonged periods of sadness or despair, detachment, loss of appetite, trouble sleeping, or thoughts of suicide. Depression is one of the Foundation’s greatest areas of investment, in hopes of finding treatments—and maybe even cures—for these difficult, often lifelong conditions.
Active Research
Striatum-Targeted Anhedonia Rapid Treatment (START): a novel transcranial magnetic stimulation paradigm for treating symptoms of anhedonia in depression | Riddle | $38,280
Striatum-Targeted Anhedonia Rapid Treatment (START): a novel transcranial magnetic stimulation paradigm for treating symptoms of anhedonia in depression 2021 Award: $38,280 Anhedonia, the inability to experience pleasure, is notoriously difficult to treat and predicts [...]
A Pilot Study of Psilocybin-Assisted Therapy in Treatment-Resistant Depression: acute changes, duration of effect and predictors of response | McClure | $101,078
A Pilot Study of Psilocybin-Assisted Therapy in Treatment-Resistant Depression: acute changes, duration of effect and predictors of response 2021 Award: $101,078 Treatment Resistance in Major Depressive Disorder (TRD) is a common and serious condition [...]
Depression in the Menopause Transition: Stress and Inflammation as Pathways of Risk | Fiacco | $31,107
Depression in the Menopause Transition: Stress and inflammation as pathways of risk 2020 Award: $31,107 In the transition to menopause (perimenopause), depressive symptoms are very common and there is a 2-4 fold increased risk to [...]
Mechanism of Action of Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder | Frohlich | $100,000
Mechanism of Action of Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder 2018 Award: $100,000 Major depressive disorder (MDD) has devastating effects on patients and their families, including an increased risk [...]
The Genomics of Severe Major Depressive Disorder (MDD) and Response to Electroconvulsive Therapy (ECT) | Soda | $39,990
The Genomics of Severe Major Depressive Disorder (MDD) and Response to Electroconvulsive Therapy (ECT) 2018 Award: $39,990 Depression is the leading cause of disability worldwide. It can lead to suicide which is the second [...]