Angel Oak Creative Support, Author at Foundation of Hope

Cellular and Molecular Mechanisms Governing Cortical Surface Area Overgrowth in iPSC-derived Neural Cells from Longitudinally Characterized Autism Individuals | Hazlett | $49,720

Cellular and Molecular Mechanisms Governing Cortical Surface Area Overgrowth in iPSC-derived Neural Cells from Longitudinally Characterized Autism Individuals 2018 Award: $49,720 Many individuals with autism spectrum disorder exhibit larger brain volumes early in life. By mimicking and studying brain cells from subjects with ASD and subjects without ASD, Dr. Hazlett and her team are working to determine the underlying pathologies of brain overgrowth. These results will help identify biological markers which will inform more personalized early treatments for ASD. Need/Problem: Autism spectrum disorder (ASD) is an etiologically heterogeneous disorder that affects 1 in 68 individuals, and confers a lifelong burden to most affected individuals and their families. ASD has been consistently characterized by early brain overgrowth in neuroimaging studies. Grant Summary: We will generate and study neural cells from individuals with ASD and matched controls who have been profiled [...]

Functional Development Abnormalities Associated with Genetic Risk of Bipolar during Infancy | Gao | $71,302

Functional Development Abnormalities Associated with Genetic Risk of Bipolar during Infancy 2013 Award: $71,302 Bipolar disorder (BD) is a common psychiatric illness affecting ~1% to 2% of the population, which is characterized by affective symptoms varying between depression and mania. However, there is a profound lack of knowledge regarding the brain’s functional disruption mechanism underlying this disorder, especially during early childhood which is increasingly recognized as a critical time for this neurodevelopmental disorder. The use of neuroimaging technology to study infants with a genetic risk of BD (biological mother diagnosed with BD) provides a wonderful opportunity to investigate the earliest functional disruption mechanisms related to this disorder, which is critical for the derivation of new early diagnosis and intervention strategies. Dr. Wei Gao, Assistant Professor of Radiology and Biomedical Imaging Research Center (BRIC) at the University of North Carolina [...]

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