Jennifer Gibson, Author at Foundation of Hope

29 04, 2025

Brain Reward Changes in Premenstrual Depression | Dr. Christopher Sikes-Keilp | $50,000

Brain Reward Changes in Premenstrual Depression 2025 Award: $50,000 Many women with depression experience a worsening of their depressive symptoms during the week before their menstrual period, adding to the burden of their illness. Although increased symptoms appear related to cycle-based changes in the hormones estradiol and progesterone, the underlying neural mechanisms are not known. In this study, we are looking at how the natural premenstrual decline in estradiol and progesterone affects brain reward function in women with premenstrual worsening of their depressive symptoms. Need/Problem: Many women with depression experience a worsening of their depressive symptoms during the week before their menstrual period, adding to burden of their illness. However, no evidence-based treatments for premenstrual exacerbations of depression exist. Grant Summary: Using a safe and validated hormone stabilization protocol that prevents the natural decline in the ovarian hormones estradiol [...]

29 04, 2025

Mapping CSF Patterns For Early Autism Diagnosis and Intervention | Dr. Roza Vlasova | $51,690

Mapping CSF Patterns To Improve Early Autism Diagnosis and Intervention 2025 Award: $51,690 Cerebrospinal fluid (CSF) is a clear fluid that circulates through the nervous system, playing a key role in brain development, nutrient delivery, and immune surveillance. Infants who are later diagnosed with autism often show an increase in CSF volume, but the causes of this increase remain unknown. In this project, we will investigate how CSF moves in the brains of these infants using advanced MRI techniques. Tracking early changes in CSF dynamics may reveal important biomarkers and enhance our understanding of how disrupted CSF motion contributes to autism. These findings will be a critical first step toward developing earlier diagnostic tools and targeted interventions. Need/Problem: Cerebrospinal fluid (CSF) is a clear fluid that circulates through the nervous system, supporting brain development, nutrient delivery, and immune protection. [...]

29 04, 2025

Improving Developmental Outcomes Through Family Navigation | Dr. Kelly Caravella | $53,800

Improving Developmental Outcomes for Rural Toddlers Through Family Navigation 2025 Award: $53,800 Long delays to diagnosis and treatment are unfortunately common for many families with autistic toddlers, especially those living in rural areas. Our study investigates whether a systems-focused intervention can reduce these treatment delays and improve developmental outcomes for young children with autism. Join us in advancing faster, more effective, and family-centered autism care. Need/Problem: Early diagnosis of autism is important, however, it must be followed by starting autism-specific treatments quickly to help children meet their developmental goals. Unfortunately, many families, especially those in rural areas, face long delays in getting these treatments due to a lack of specialists, travel difficulties, and less awareness about autism service availability. We need a family-centered approach to help these families overcome these barriers and get the care they need sooner. Grant [...]

29 04, 2025

Investigation of D2 and 5-HT2A Genetic Variants on Antipsychotic Responsiveness | Dr. Ranran French | $57,705

Investigation of D2 and 5-HT2A Genetic Variants on Antipsychotic Responsiveness 2025 Award: $57,705 Many patients with schizophrenia endure months or even years of suboptimal treatment before finding an antipsychotic that works. This project aims to change that by identifying how individual genetic differences in brain receptors affect treatment response. The ultimate goal: a personalized tool that helps doctors choose the right antipsychotic the first time. Need/Problem: Antipsychotics are the cornerstone of schizophrenia treatment, yet patient responses vary widely. Many patients endure a lengthy trial-and-error process during medication selection, which often leads to prolonged symptoms and hospitalization, unnecessary side effects, and poor long-term outcomes. A precision-medicine approach is urgently needed to guide antipsychotic selection using a person’s unique genetic information. Grant Summary: This study will analyze how genetic variations in two key neuroreceptors—D2 and 5-HT2A—affect a patient’s long-term clinical stability [...]

29 04, 2025

Functional Impact of Eating Disorders to Inform Rehabilitation | Dr. Rachel Presskreischer | $58,756

Understanding the Functional Impact of Eating Disorders to Inform Rehabilitation 2025 Award: $58,756 Eating disorders can have devastating impacts on school, work, and relationships similar to the impacts of schizophrenia, bipolar disorder, and other severe psychiatric illness. While interventions exist to address these effects for people with other psychiatric conditions, there are currently no interventions tailored specifically to the needs of individuals with eating disorders. In this study we will gain insight into the nature of challenges in these areas directly from both people with eating disorders and caregivers or partners to inform the design of future interventions. Need/Problem: Adults with eating disorders can have impairment in educational attainment, employment, social relationships, and health-related quality of life. While psychiatric rehabilitation interventions have been designed to address these challenges for people with other psychiatric illnesses, there are no targeted interventions [...]

29 04, 2025

Predicting ASD comorbid Anxiety in Early Childhood | Dr. Yoonmi Hong | $59,102

Predicting ASD comorbid Anxiety in Early Childhood via Multi-modality MRI 2025 Award: $59,102 Can the structure of a child's brain predict their risk for developing anxiety? Our groundbreaking study harnesses the power of deep learning to decode the complex relationship between brain architecture and anxiety vulnerability in children with autism. By analyzing cortical morphometry and white matter microstructure, we aim to identify neuroimaging biomarkers that could revolutionize early detection and intervention strategies. This research bridges a critical knowledge gap in understanding how brain structure relates to anxiety in early childhood autism, potentially transforming how we approach mental health care in neurodevelopmental disorders. Need/Problem: Research shows changes in brain networks and structure in adults with autism who have anxiety or ADHD, but we know very little about how brain structure relates to anxiety in young children with autism. The high [...]

29 04, 2025

Suicide Prevention Among Perinatal Psychiatric Inpatients | Dr. Parisa Kaliush | $59,999

Suicide prevention among perinatal psychiatric inpatients: A randomized clinical trial 2025 Award: $59,999 Suicide is a leading cause of postpartum maternal deaths, yet no suicide prevention programs exist that are designed specifically for pregnant and postpartum women. This is a huge gap in maternal mental healthcare that we will address with this project. Thanks to the Foundation of Hope, we will be able to design and test the first ever perinatal-specific suicide prevention program for women who are experiencing high levels of psychological distress and suicide risk. Need/Problem: Suicide is a leading cause of postpartum maternal deaths in the United States, yet no perinatal suicide prevention programs exist. Some interventions indirectly reduce perinatal suicide risk by treating other mental health conditions, like postpartum depression, but these interventions are not always feasible for higher-risk patients who need more rapid, targeted [...]

29 04, 2025

Modeling Genetic Risk for Schizophrenia | Dr. Robert Mealer | $60,000

Modeling genetic risk for schizophrenia in human-derived neurons 2025 Award: $60,000 Over 75% of the risk for developing schizophrenia is determined by the genes one inherits. In this project, the Mealer and Heinzen Labs plan to leverage recent advances in genetic studies of schizophrenia and neurons generated from human stem cells to better understand changes in brain development and function that could one day be used design better treatments for severe mental illness. Need/Problem: Antipsychotic medications, which are used to treat many different psychiatric conditions including schizophrenia, were not developed based on our knowledge of what is changed in the brain or how these disorders are inherited. As such, these treatments commonly provide limited symptom relief and do not appear to alter disease course or offer a chance at cure. Thus, there is incredible opportunity and need for rationally [...]

29 04, 2025

Reimagining Alzheimer’s as a Lifespan Condition| Dr. Guorong Wu & Dr. Marissa DiPiero | $198,959

Understanding Neurodevelopmental Origin of Alzheimer's Disease Using Lifespan Approach 2025 Award: $198,959 Early-life development is characterized by dramatic changes, impacting lifespan function more than changes in any other period. Although the developmental origins of neurodegenerative diseases in later life are recognized, there is a lack of detailed longitudinal neuroimaging studies that link early development and brain maturation with the neurobiological mechanisms of dementia. We will answer the outstanding questions by capitalizing on large-scale neuroimaging data alongside environmental exposures and demographic information. Need/Problem: Human brain development spans the first thirty years of life, with brain maturation during the first two decades playing a critical role in shaping its vulnerability to neurodegenerative diseases as we age. However, due to the absence of large-scale lifespan data ranging from childhood to late adulthood, our understanding of early-life dementia risk remains limited. Grant Summary: [...]

29 04, 2025

CF-tACS and Mobile EEG for Treating Anxiety in Young Adults | Dr. Zachary Feldman | $199,624

Cross Frequency Transcranial Alternating Current Stimulation (CF-tACS) with mobile EEG for the treatment of Generalized Anxiety Disorder: A Randomized Controlled Pilot Trial 2025 Award: $199,624 While medications and psychotherapy can be very effective for anxiety, many people with anxiety have side effects with medications, don’t have access to therapy, or don’t get full relief from symptoms even with treatment. In this study, we are testing an exciting new technology that utilizes low-level electric currents to gently modify brain activity to treat anxiety. We will investigate the effectiveness of this new treatment in treating anxiety, and we will record daily EEG measurements to see which changes in brain activity lead to the most improvement. Need/Problem: Anxiety disorders are quite common, and many people with anxiety disorders do not get to a point of remission from symptoms and/or have side effects [...]

jgibson@walkforhope.com

About Jennifer Gibson