Grant Details: Around 30% of AN patients develop a chronic, relapsing course. In those who do recover, the recovery process is long (7 years on average).8 The AN treatment is weak with no efficacious treatments and no medications targeting the core biology of the illness. Thus, AN ranks among the ten leading causes of disability in young women and has the highest mortality rate of any psychiatric illness. Funding for AN research is limited. In a white paper published by the National Institute of Mental Health (NIMH), director Dr. Thomas Insel wrote, “eating disorders …receive less funding than they ‘should’ based on” estimates of the life lost to illness. Funding for innovative research on AN etiology and biology is desperately needed to help us a) prevent AN and b) treat AN. Translating these findings back to prevention efforts, clinical care, and future pharmacotherapy, has potential to reduce the unacceptably high societal and personal burden on patients with AN and their families.
The proposed research will examine how restrictive eating develops in childhood and will ultimately assist in the early detection and prevention of eating disorders. The project leverages existing resources from a K01 grant (PI: Zerwas) and data from The Norwegian Mother and Child Study (MoBa).8,9 Norwegian and NIMH initial investment in MoBa has been estimated at ~$45 million dollars. MoBa is a longitudinal, prospective birth cohort study and biobank of ~114,000 offspring and ~90,000 mothers who have been followed up routinely since pregnancy and as such is a unique resource. Data are currently available from pregnancy to the most recent survey with 8 year olds; children in the sample are turning 12 years old and completing another survey this year.
The overarching aim of this proposal is to understand risk and causal pathways to the development of restrictive eating which is a putative childhood prodrome for AN. Describing the genetic and environmental pathways to disordered eating represents our greatest opportunity to avert the development of anorexia nervosa and to reduce the devastating personal, familial, and societal burden caused by the disorder.