Research

/Research
16 04, 2019

Characterizing the Hormone Sensitive Phenotype of Postpartum Depression: An Experimental Investigation of Mood and Behavior | Schiller

Characterizing the Hormone Sensitive Phenotype of Postpartum Depression: An Experimental Investigation of Mood and Behavior Need/Problem: Despite decades of research, little is known about the biological causes of postpartum depression. Our past research showed that changes in pregnancy hormone levels cause depression in some women, but at present, there is no simple way to identify these women. Grant Summary: This research provides a novel approach to testing risk for postpartum depression. Goals and Projected Outcomes: The purpose of this project is to test two simple, non-invasive approaches to identifying women at high-risk for postpartum depression. The projected outcome of this project is the ability to distinguish those at high and low risk for postpartum depression using minimally invasive, easy-to-implement protocols, thus potentially enabling the identification of women at risk for postpartum depression prior to its development. Crystal [...]

16 04, 2019

Depression Susceptibility in Adolescent Females: Estrogen Variability, Stress Exposure, and Fronto-Limbic Brain Dynamics | Andersen

Depression Susceptibility in Adolescent Females: Estrogen Variability, Stress Exposure, and Fronto-Limbic Brain Dynamics Need/Problem: Dramatic fluctuations in reproductive hormones (e.g., estrogen), refinement of brain circuitry involved in cognitive and emotional processing, and elevated psychosocial stress during the pubertal transition (peripuberty) accompany a substantially increased risk for depression, particularly for adolescent girls. Although normal changes in estrogen provoke affective symptoms in vulnerable women during reproductive events, the role of changing estrogen levels in depression risk has not been studied in peripubertal girls. Furthermore, the neurophysiologic mechanisms underlying the vulnerability to estrogen fluctuations have yet to be identified. Grant Summary: : Estrogen exerts significant modulatory effects on the cortisol stress response and brain circuitry involved in regulating affective (mood) state. With the Foundation of Hope’s support, this research will use a novel multimodal approach involving precise ovarian hormone measurements, neurophysiological assessments of [...]

16 04, 2019

Next Generation Non-Invasive Brain Stimulation: A Novel Solution Enabled by Mobile Technology and Big Data | Frohlich | $200,000

Next Generation Non-Invasive Brain Stimulation: A Novel Solution Enabled by Mobile Technology and Big Data Award: $200,000 Need/Problem: Psychiatry urgently needs new treatment paradigms that are effective, safe, and affordable. Non-invasive brain stimulation such as transcranial current stimulation has the potential to take such a role of a disruptive technology that will fundamental improve the landscape of treatment options for psychiatric disorders. Grant Summary: Today, the field of transcranial current stimulation (TCS) is dominated by small, underpowered studies performed by individual, relatively isolated research groups. We argue that the solution to this problem is new device technology that allows the centralized execution and large-scale analysis of multiple TCS clinical studies. Goals and Projected Outcomes: To implement and evaluate a networked and portable TCS device and server-side cloud-based infrastructure for remote control and collection of data on TCS and its [...]

16 04, 2019

Achieving Synergy with Multimodal Brain Stimulation: Electricity meets Magnetism | Frohlich | $156,613

Achieving Synergy with Multimodal Brain Stimulation: Electricity meets Magnetism Award: $156,613 Need/Problem: One effective treatment strategies for mental illnesses is to combine medications to achieve maximal therapeutic benefit. In contrast, despite the emergence of multiple, different forms of non-invasive brain stimulation for the treatment of mental illnesses, very little is known about the potential therapeutic synergy of different forms of non-invasive brain stimulation. Grant Summary: This is the first study of its kind to investigate the targeted combination of transcranial magnetic stimulation and transcranial alternating current stimulation (tACS) for modulating brain rhythms. Goals and Projected Outcomes: The goal of this study is to introduce a novel therapeutic approach which is based on leveraging network neuroscience to develop individualized treatment strategies. Dr. Flavio Frohlich Grant Details: By combining tACS and TMS, we will accelerate [...]

16 04, 2019

Mechanism of Action of Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder | Frohlich | $100,000

Mechanism of Action of Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder Award: $100,000 Need/Problem: Depression is a serious illness and many patients do not find relief with the current treatment options. Our Carolina Center for Neurostimulation has pioneered a novel form of non-invasive brain stimulation that applies a very weak but smart current to modulate brain rhythms. This potential new treatment is very safe (most patients cannot even feel the electricity) and potentially efficacious for the treatment of depression. Based on promising pilot data, we are excited to move ahead with this new study to better understand how the stimulation modulates brain rhythms such that we can further optimize the stimulation to develop personalized treatment protocols. Grant Summary: In collaboration with Dr. David Rubinow, Chair of the Department of Psychiatry at UNC – Chapel Hill, [...]

16 04, 2019

The genomics of severe major depressive disorder (MDD) and response to electroconvulsive therapy (ECT) | Soda | $39.990

The genomics of severe major depressive disorder (MDD) and response to electroconvulsive therapy (ECT) Award: $39,990 Depression is the leading cause of disability worldwide. It can lead to suicide which is the second leading cause of death in 15-29 year olds. We need to identify patients with the most severe forms of depression, characterize them well, and include these patients in genomic studies. We know that such an approach will lead to new discoveries faster than studying patients with more mild forms of these disorders. We think that we have a way to do this. We want to identify people that have been treated with electroconvulsive therapy (ECT) for depression and include them in genetic studies. We think that findings from this study can lead to predictive algorithms. We want to learn whether we can, very early on in [...]

16 04, 2019

Identifying Susceptibility Loci for Tourette’s Syndrome in a Densely Affected Pedigree | Crowley

Identifying Susceptibility Loci for Tourette’s Syndrome in a Densely Affected Pedigree Need/Problem: Tourette’s Syndrome is a highly genetic condition with no effective treatment. We need to identify the genetic causes of this disorder in order to develop treatments. Grant Summary: This grant will take advantage of an extraordinary family from England that is both large and enriched for Tourette’s Syndrome in order to identify genes associated with Tourette’s Syndrome. Goals and Projected Outcomes: The goal of our study is to identify a gene or genes with altered function in this family, that predisposes individuals to develop Tourette’s Syndrome. James J. Crowley, PhD Grant Details: Tourette’s Syndrome (TS) is a poorly-understood neuropsychiatric illness characterized by recurrent, non-rhythmic tics. Diagnostic criteria for TS require age of onset <18 years, multiple motor and at least one vocal [...]

16 04, 2019

Transcranial Alternating Current Stimulation to Reduce Emotional Dysregulation in Veterans with Posttraumatic Stress Disorder | Frolich & Elbogen

Transcranial Alternating Current Stimulation to Reduce Emotional Dysregulation in Veterans with Posttraumatic Stress Disorder Need/Problem: Approximately one in five military veterans suffer from posttraumatic stress disorder (PTSD). Research documents PTSD is associated with poor post-deployment adjustment in military veterans, including increased risk of suicide, homelessness, violence, criminal arrest, and unemployment. As thousands of troops return home, there is an urgent need to develop effective treatment approaches that overcome barriers, are more feasible and less time-consuming to implement, and that veterans will prefer and actually use. Grant Summary: Transcranial Alternating Current Stimulation (tACS) provides a safe, non-invasive, easy-to-administer, and cutting-edge technology and procedure that applies weak electric currents to the scalp to modulate rhythmic brain activity patterns. The objective of this project is to establish the feasibility of the tACS treatment and collect pilot efficacy and electroencephalogram (EEG) biomarkers data [...]

16 04, 2019

Functional Development Abnormalities Associated with Genetic Risk of Bipolar during Infancy | Gao

Functional Development Abnormalities Associated with Genetic Risk of Bipolar during Infancy Bipolar disorder (BD) is a common psychiatric illness affecting ~1% to 2% of the population, which is characterized by affective symptoms varying between depression and mania. However, there is a profound lack of knowledge regarding the brain’s functional disruption mechanism underlying this disorder, especially during early childhood which is increasingly recognized as a critical time for this neurodevelopmental disorder. The use of neuroimaging technology to study infants with a genetic risk of BD (biological mother diagnosed with BD) provides a wonderful opportunity to investigate the earliest functional disruption mechanisms related to this disorder, which is critical for the derivation of new early diagnosis and intervention strategies. Dr. Wei Gao, Assistant Professor of Radiology and Biomedical Imaging Research Center (BRIC) at the University of North Carolina at Chapel Hill [...]

16 04, 2019

Early Brain Development via Deep Learning of DNA | Xia | $39,742

Early Brain Development via Deep Learning of DNA Award: $39,742 Need/Problem: Innovative methodological strategies are urgently needed to predict short-term and long-term cognitive outcome at early life so that early intervention can be implemented before any cognitive delay appears. Grant Summary: This grant is to develop deep convolutional neural networks to build a predictive model for early brain development through genome-wide DNA markers and developmental trajectories of cortical thickness and surface area. Goals and Projected Outcomes: The goal of this study is to develop the first deep learning procedure to predict early brain development using data from two well-characterized population cohorts studied from birth through 2 years of age. The success of this study will present strong proof that deep learning predicting neurodevelopment and cognitive functions is effective and powerful using genome-wide DNA markers, while none of other competing [...]


Notice: ob_end_flush(): failed to send buffer of zlib output compression (0) in /home/walkforhope/public_html/wp-includes/functions.php on line 4339

Notice: ob_end_flush(): failed to send buffer of zlib output compression (0) in /home/walkforhope/public_html/wp-includes/functions.php on line 4339