WOMEN’S MOOD DISORDERS
$860,396 awarded to research since 1985
Women’s Mood Disorders encompass perinatal mood and anxiety disorders, and menstrual-related mood disorders. These disorders include Depression during Pregnancy, Postpartum Depression (PPD), Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), Perimenopausal Depression. In 2018 alone, 12.8% of U.S. mothers reported experiencing postpartum depression. That’s 1 in 8 mothers. But, that statistic does not take into account undiagnosed PPD, which is estimated to put the number closer to 20% of moms, or 1 in 5.
Active Research
The gut microbiome and Perinatal Mood and Anxiety Disorders (PMAD): A pilot study to examine the microbiome in relation to perinatal changes in stress and immune systems | Kimmel
The gut microbiome and Perinatal Mood and Anxiety Disorders (PMAD): A pilot study to examine the microbiome in relation to perinatal changes in stress and immune systems Need/Problem: PMAD are common and can have [...]
Genomics of Postpartum Depression–Action towards Causes and Treatment (gPACT); PACT for the Cure | Meltzer-Brody & Sullivan
Genomics of Postpartum Depression–Action towards Causes and Treatment (gPACT); PACT for the Cure Need/Problem: Postpartum depression (PPD) and postpartum psychosis (PPP) affect millions of women worldwide and are the leading cause of maternal morbidity [...]
Single cell transcriptional profiling to identify novel neurocircuit targets for reproductive mood disorders | Stuber
Single cell transcriptional profiling to identify novel neurocircuit targets for reproductive mood disorders Need/Problem: There are few rational strategies for targeting neuronal cell types in the brain for the treatment of neuropsychiatric disease. We [...]
Characterizing the Hormone Sensitive Phenotype of Postpartum Depression: An Experimental Investigation of Mood and Behavior | Schiller
Characterizing the Hormone Sensitive Phenotype of Postpartum Depression: An Experimental Investigation of Mood and Behavior Need/Problem: Despite decades of research, little is known about the biological causes of postpartum depression. Our past research showed [...]
Depression Susceptibility in Adolescent Females: Estrogen Variability, Stress Exposure, and Fronto-Limbic Brain Dynamics | Andersen
Depression Susceptibility in Adolescent Females: Estrogen Variability, Stress Exposure, and Fronto-Limbic Brain Dynamics Need/Problem: Dramatic fluctuations in reproductive hormones (e.g., estrogen), refinement of brain circuitry involved in cognitive and emotional processing, and elevated psychosocial stress [...]
gPACT – a rapid large & inexpensive study of Postpartum Depression | Meltzer-Brody | $99,000
gPACT – a rapid large & inexpensive study of Postpartum Depression Award: $99,000 Dr. Samantha Meltzer-Brody helped assemble an international team of researchers and clinicians who, using open-source Apple software, could gather information from [...]