WOMEN’S MOOD DISORDERS
$1,068,483 awarded to research since 1985
Women’s Mood Disorders encompass perinatal mood and anxiety disorders, and menstrual-related mood disorders. These disorders include Depression during Pregnancy, Postpartum Depression (PPD), Premenstrual Syndrome (PMS), Premenstrual Dysphoric Disorder (PMDD), Perimenopausal Depression. In 2018 alone, 12.8% of U.S. mothers reported experiencing postpartum depression. That’s 1 in 8 mothers. But, that statistic does not take into account undiagnosed PPD, which is estimated to put the number closer to 20% of moms, or 1 in 5.
Active Research
Mechanisms of Brexanolone Therapeutics in Postpartum Depression | Morrow | $48,070
Mechanisms of Brexanolone Therapeutics in Postpartum Depression 2020 Award: $48,070 Depression is associated with abnormal activation of inflammatory immune signals in the blood and the brain. We recently discovered that the endogenous steroid allopregnanolone [...]
Microbiome and Methylation (M&M): A Source of Information for Precision Medicine | Kimmel | $42,000
Microbiome and Methylation (M&M): A Source of Information for Precision Medicine 2020 Award: $42,000 Despite greater recognition of the need to treat Perinatal Depression and Anxiety that can affect one in five women, current [...]
Depression in the Pubertal Transition: Circadian Rhythms and Sleep Impairment as Mechanisms of Risk | Andersen | $37,920
Depression in the pubertal transition: Circadian rhythms and sleep impairment as mechanisms of risk 2020 Award: $37,920 Puberty is characterized by dramatic reproductive hormone instability, sleep and circadian rhythm disturbances, and an increased risk [...]
Genomics of Postpartum Depression–Action towards Causes and Treatment (gPACT); PACT for the Cure | Meltzer-Brody & Sullivan | $99,000
Genomics of Postpartum Depression–Action towards Causes and Treatment (gPACT); PACT for the Cure 2015 Award: $99,000 Dr. Samantha Meltzer-Brody helped assemble an international team of researchers and clinicians who, using open-source Apple software, could [...]
Single Cell Transcriptional Profiling to Identify Novel Neurocircuit Targets for Reproductive Mood Disorders | Stuber | $45,000
Single cell transcriptional profiling to identify novel neurocircuit targets for reproductive mood disorders 2016 Award: $45,000 It’s known that reproductive mood disorders—like postpartum depression, premenstrual dysphoric disorder, and perimenopausal depression—are largely caused by fluctuations [...]
Characterizing the Hormone Sensitive Phenotype of Postpartum Depression: An Experimental Investigation of Mood and Behavior | Schiller | $39,357
Characterizing the Hormone Sensitive Phenotype of Postpartum Depression: An Experimental Investigation of Mood and Behavior 2017 Award: $39,357 Prior research has demonstrated that changing hormone levels trigger depression in some women already at high [...]
Depression Susceptibility in Adolescent Females: Estrogen Variability, Stress Exposure, and Fronto-Limbic Brain Dynamics | Andersen | $38,710
Depression Susceptibility in Adolescent Females: Estrogen Variability, Stress Exposure, and Fronto-Limbic Brain Dynamics 2018 Award: $38,710 Puberty is characterized by dramatic reproductive hormone instability, heightened interpersonal stress and an increased risk for depression, especially [...]
Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause | Schiller | $40,000
Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause 2016 Award: $40,000 Owing largely to a steep drop in estrogen production, perimenopausal women are 14 [...]