Depression

//Depression
16 04, 2019

Next Generation Non-Invasive Brain Stimulation: A Novel Solution Enabled by Mobile Technology and Big Data | Frohlich | $200,000

Next Generation Non-Invasive Brain Stimulation: A Novel Solution Enabled by Mobile Technology and Big Data Award: $200,000 Need/Problem: Psychiatry urgently needs new treatment paradigms that are effective, safe, and affordable. Non-invasive brain stimulation such as transcranial current stimulation has the potential to take such a role of a disruptive technology that will fundamental improve the landscape of treatment options for psychiatric disorders. Grant Summary: Today, the field of transcranial current stimulation (TCS) is dominated by small, underpowered studies performed by individual, relatively isolated research groups. We argue that the solution to this problem is new device technology that allows the centralized execution and large-scale analysis of multiple TCS clinical studies. Goals and Projected Outcomes: To implement and evaluate a networked and portable TCS device and server-side cloud-based infrastructure for remote control and collection of data on TCS and its [...]

16 04, 2019

Achieving Synergy with Multimodal Brain Stimulation: Electricity meets Magnetism | Frohlich | $156,613

Achieving Synergy with Multimodal Brain Stimulation: Electricity meets Magnetism Award: $156,613 Need/Problem: One effective treatment strategies for mental illnesses is to combine medications to achieve maximal therapeutic benefit. In contrast, despite the emergence of multiple, different forms of non-invasive brain stimulation for the treatment of mental illnesses, very little is known about the potential therapeutic synergy of different forms of non-invasive brain stimulation. Grant Summary: This is the first study of its kind to investigate the targeted combination of transcranial magnetic stimulation and transcranial alternating current stimulation (tACS) for modulating brain rhythms. Goals and Projected Outcomes: The goal of this study is to introduce a novel therapeutic approach which is based on leveraging network neuroscience to develop individualized treatment strategies. Dr. Flavio Frohlich Grant Details: By combining tACS and TMS, we will accelerate [...]

16 04, 2019

Mechanism of Action of Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder | Frohlich | $100,000

Mechanism of Action of Transcranial Alternating Current Stimulation for the Treatment of Major Depressive Disorder Award: $100,000 Need/Problem: Depression is a serious illness and many patients do not find relief with the current treatment options. Our Carolina Center for Neurostimulation has pioneered a novel form of non-invasive brain stimulation that applies a very weak but smart current to modulate brain rhythms. This potential new treatment is very safe (most patients cannot even feel the electricity) and potentially efficacious for the treatment of depression. Based on promising pilot data, we are excited to move ahead with this new study to better understand how the stimulation modulates brain rhythms such that we can further optimize the stimulation to develop personalized treatment protocols. Grant Summary: In collaboration with Dr. David Rubinow, Chair of the Department of Psychiatry at UNC – Chapel Hill, [...]

16 04, 2019

The genomics of severe major depressive disorder (MDD) and response to electroconvulsive therapy (ECT) | Soda | $39.990

The genomics of severe major depressive disorder (MDD) and response to electroconvulsive therapy (ECT) Award: $39,990 Depression is the leading cause of disability worldwide. It can lead to suicide which is the second leading cause of death in 15-29 year olds. We need to identify patients with the most severe forms of depression, characterize them well, and include these patients in genomic studies. We know that such an approach will lead to new discoveries faster than studying patients with more mild forms of these disorders. We think that we have a way to do this. We want to identify people that have been treated with electroconvulsive therapy (ECT) for depression and include them in genetic studies. We think that findings from this study can lead to predictive algorithms. We want to learn whether we can, very early on in [...]

9 07, 2018

Longitudinal Assessment of Mental Health Needs of Parents with Advanced Cancer | Park | $39,000

Longitudinal Assessment of Mental Health Needs of Parents with Advanced Cancer Award: $39,000 Need/Problem: Parents with advanced cancer experience unique psychological concerns due to simultaneously raising and supporting their children while adjusting to the physical and psychological effects of life-limiting illness. Their children are at increased risk of long-term psychological effects from parental cancer and early parental loss and their caregivers or partners suffer from high rates of depression and anxiety. Grant Summary:  We plan to conduct a mixed-methods, cohort study of parents with advanced cancer who have dependent-age children using semi-structured interviews and six validated measures to examine parental concerns, coping strategies to alleviate these concerns, physical and psychological symptoms and quality of life. Goals & Projected Outcomes: The goals are the following: 1)    To identify areas of peak psychological symptom burden that are amenable to future intervention [...]


Notice: ob_end_flush(): failed to send buffer of zlib output compression (0) in /home/walkforhope/public_html/wp-includes/functions.php on line 4339

Notice: ob_end_flush(): failed to send buffer of zlib output compression (0) in /home/walkforhope/public_html/wp-includes/functions.php on line 4339