Depression

//Depression
9 07, 2018

Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause | Schiller | $40,000

Effects of a Tissue Selective Estrogen Complex (TSEC) on Depression and the Neural Reward System in the Perimenopause Award: $40,000 Owing largely to a steep drop in estrogen production, perimenopausal women are 14 times more likely to experience symptoms of depression than premenopausal women. While estrogen therapy can alleviate symptoms of depression, it’s also associated with an increased risk of breast and uterine cancer, and so many women decline it. However, a promising new FDA-approved drug bolsters estrogen while mitigating cancer risks. Researchers will test this drug’s capacity to alleviate depression in women whose symptoms have manifested with the onset of menopause. Crystal Schiller, Ph.D. Need/Problem: The risk for developing depression increases 14-fold during the transition to menopause. Despite evidence that estrogen plays a role in depression during menopause, the use of [...]