Jennifer Gibson, Author at Foundation of Hope

29 04, 2025

Modeling Genetic Risk for Schizophrenia | Dr. Robert Mealer | $60,000

Modeling genetic risk for schizophrenia in human-derived neurons 2025 Award: $60,000 Over 75% of the risk for developing schizophrenia is determined by the genes one inherits. In this project, the Mealer and Heinzen Labs plan to leverage recent advances in genetic studies of schizophrenia and neurons generated from human stem cells to better understand changes in brain development and function that could one day be used design better treatments for severe mental illness. Need/Problem: Antipsychotic medications, which are used to treat many different psychiatric conditions including schizophrenia, were not developed based on our knowledge of what is changed in the brain or how these disorders are inherited. As such, these treatments commonly provide limited symptom relief and do not appear to alter disease course or offer a chance at cure. Thus, there is incredible opportunity and need for rationally [...]

29 04, 2025

Reimagining Alzheimer’s as a Lifespan Condition| Dr. Guorong Wu & Dr. Marissa DiPiero | $198,959

Understanding Neurodevelopmental Origin of Alzheimer's Disease Using Lifespan Approach 2025 Award: $198,959 Early-life development is characterized by dramatic changes, impacting lifespan function more than changes in any other period. Although the developmental origins of neurodegenerative diseases in later life are recognized, there is a lack of detailed longitudinal neuroimaging studies that link early development and brain maturation with the neurobiological mechanisms of dementia. We will answer the outstanding questions by capitalizing on large-scale neuroimaging data alongside environmental exposures and demographic information. Need/Problem: Human brain development spans the first thirty years of life, with brain maturation during the first two decades playing a critical role in shaping its vulnerability to neurodegenerative diseases as we age. However, due to the absence of large-scale lifespan data ranging from childhood to late adulthood, our understanding of early-life dementia risk remains limited. Grant Summary: [...]

29 04, 2025

CF-tACS and Mobile EEG for Treating Anxiety in Young Adults | Dr. Zachary Feldman | $199,624

Cross Frequency Transcranial Alternating Current Stimulation (CF-tACS) with mobile EEG for the treatment of Generalized Anxiety Disorder: A Randomized Controlled Pilot Trial 2025 Award: $199,624 While medications and psychotherapy can be very effective for anxiety, many people with anxiety have side effects with medications, don’t have access to therapy, or don’t get full relief from symptoms even with treatment. In this study, we are testing an exciting new technology that utilizes low-level electric currents to gently modify brain activity to treat anxiety. We will investigate the effectiveness of this new treatment in treating anxiety, and we will record daily EEG measurements to see which changes in brain activity lead to the most improvement. Need/Problem: Anxiety disorders are quite common, and many people with anxiety disorders do not get to a point of remission from symptoms and/or have side effects [...]

29 04, 2025

Neural Networks and Preteen Suicide Risk | Dr. Adam Miller | $200,000

Neural Networks Underlying Preteen Social Motivation: A novel risk factor for preteen suicide 2025 Award: $200,000 Why do some preteen girls become vulnerable to suicide while others don’t, even when they face similar social stress? This first of its kind study will use brain scans, hormone data, and behavioral assessments to explore how the timing of puberty affects brain development and suicide risk. By identifying early warning signs, we aim to support earlier, more effective interventions to protect youth mental health. Need/Problem: Youth suicide is a leading cause of death, with many preteens experiencing suicidal thoughts and behaviors, especially in response to interpersonal stress. However, it remains unclear why only some youth are vulnerable despite widespread exposure to stress. There is a critical need to identify early developmental risk factors—like the timing of puberty—that may influence brain development and [...]

29 04, 2025

Neurobiological mechanisms of susceptibility to estradiol fluctuation in female adolescents at risk of suicide: An experimental approach | Dr. Elizabeth Andersen | $200,000

Neurobiological mechanisms of susceptibility to estradiol fluctuation in female adolescents at risk of suicide: An experimental approach 2025 Award: $200,000 Female adolescents are 2-3 times more likely than their male peers to experience severe mental illness, possibly due to sensitivity to changing ovarian hormones (e.g., estradiol). Yet, the biological mechanisms that contribute to this elevated risk in females remain unclear. In this study, we will examine relationships between estradiol and depressive symptoms across the adolescent menstrual cycle to identify distinct windows of vulnerability to estradiol change, and use the experimental stabilization of estradiol to isolate the role of estradiol on depressive symptoms and underlying brain circuitry in female adolescents at risk of suicide. Need/Problem: Rates of suicidal ideation and attempts increase dramatically at the adolescent transition, particularly among females, yet remarkably little is known about why. With suicide being [...]

31 01, 2025

Nicole

Nicole “It’s not your fault. You were the best part of me.” This was the text Nicole Spector received from her oldest son, Greyson, on March 26, 2020, moments before he ended his life by jumping from the 18th floor of a hotel. Greyson (Grey) Spector appeared to have it all. He was months away from graduating from Duke University and had just been accepted into Duke Law School. Nicole recalls Grey’s excitement when telling her, “I can’t believe I actually get to go there next year.” As the oldest of four, Grey was a role model to his younger brothers, who deeply adored and admired him. They always followed in his footsteps, whether it was learning an instrument, chess, lacrosse, or active debate. Because Grey did it, they did it. Despite being brilliant and [...]

31 01, 2025

Terry

Terry The Barber family’s world came crashing down on them on December 11, 2021, when Luke didn’t wake up. Ironically, on that same day, he had been planning to enter a residential treatment program. Things seemed to be turning around for Luke after years of an endless cycle of relapses. At 5:15am Luke texted his mother, Terry, to say, “Mom, I’m going to give this my best shot. I’m going to learn to love myself again.” But by 2:00pm — it was too late. From an early age, Luke wrestled with ADHD and severe anxiety, and was also later diagnosed with Bipolar Disorder. But even his mom and close-knit siblings couldn’t see Luke’s daily battle, which engulfed him in darkness because he was an expert at masking his illness. Luke never met a stranger, and [...]

24 09, 2024

Annah

Annah “Start-up weekend, start-up weekend” … I can still see Jen standing in front of a room of 83 students getting them to chant “start-up… weekend” back and forth. We were getting my 4th and 5th grade students ready for 2 days of participating in their very own shark tank style design process. Over those two days Jen helped inspire innovation amongst 9-11 year olds and helped them learn the real world principles of entrepreneurship. Jen had such joy all over her face teaching these students how to come up with their own unique ideas. She taught them about the value of failure and group work, dreaming big, and believing in your ideas. When those kids were chanting start-up weekend they had no idea what they were even getting ready to do. But Jen was [...]

20 08, 2024

Dianna

Dianna It was a Thursday night. I was wearing navy blue pajamas with peaches on them when I heard someone knocking on my front door. It was a loud knock, the kind you feel in your gut that you can't ignore. I immediately got up and opened the door and in front of me stood four police officers. I remember his voice as he asked, "Are you Dianna Wagoner?" and "Is Daniel Wagoner your husband?" As I replied yes, my eyes focused on their faces, and they held a look of somber respect that I will never forget. The very next sentence changed everything: "Ma'am I'm sorry to tell you your husband has passed away." I stood there for what felt like an hour staring at them. I only asked one question: "Are you absolutely [...]

3 05, 2024

Investigating Psychiatric Symptoms of Dementia | McElligott | $110,000

Investigating Psychiatric Symptoms of Dementia 2024 Award: $110,000 Psychiatric symptoms like agitation, aggression, disinhibition, and impulsivity, amongst others, are common psychiatric symptoms that may precede cognitive decline that is associated with dementia. This project uses a mouse model of dementia (the P301S tauopathy model) to mechanistically examine these psychiatric symptoms antecedent to cognitive decline. We hypothesize that we will observe differences in neurotransmission (both dopaminergic and glutamatergic) in these animals as compared to age matched controls. Furthermore, we expect to observe differences in responses to commonly prescribed psychiatric medications in these mice. By uncovering neural mechanisms impinged upon by tauopathy, we hope to aid in the discovery of biomarkers and development of therapies to alleviate the symptoms associated with dementia. Need/Problem: Behavioral and psychiatric symptoms of dementia (including but not limited to hyperactivity, agitation, mood disturbance, aggression) often precede [...]

About Jennifer Gibson