PTSD

19 09, 2019

Epigenetic Mechanisms of Post-traumatic Stress and Depression after Sexual Assault | Dr. Anthony Zannas | $75,000

 Epigenetic Mechanisms of Post-traumatic Stress and Depression After Sexual Assault Award: $75,000 More than 40 million Americans each year present to US emergency departments (EDs) for evaluation after trauma exposure. Posttraumatic stress disorder (PTSD) and posttraumatic major depression (PMD) are common, morbid outcomes among trauma-exposed survivors that greatly reduce mental and physical health. Posttraumatic interventions to prevent PTSD and PMD are very limited, because the molecular underpinnings of these outcomes remain poorly understood. Need/Problem: National surveys indicate that 1 in 5 adult US women are sexually assaulted during their lifetime. Posttraumatic stress disorder (PTSD) and posttraumatic major depression (PMD) are common, morbid outcomes among adult women sexual assault (SA) survivors that greatly reduce mental and physical health. Posttraumatic interventions to prevent PTSD and PMD after SA are very limited, because the molecular underpinnings of these outcomes remain poorly understood. [...]

12 09, 2019

Genetic Risk Factors of Post-traumatic Stress Disorders in Solid Organ Transplant Recipients | Dr. Rebekah Nash | $39,886

Genetic Risk Factors of Post-traumatic Stress Disorders in Solid Organ Transplant Recipients Award: $39,886 Medical post-traumatic stress disorder (PTSD) can be triggered by any number of surgical or medical interventions or critical illness. For example, patients awaiting a solid organ transplant face the ever-present threat of death if a matching organ does not become available; following transplantation, they live with the ongoing risk of organ rejection. Currently, we are unable to accurately predict who will suffer from PTSD or other neuropsychiatric symptoms following transplantation. However, certain genetic variants have been associated with PTSD in the general population, and could serve as susceptibility factors for the transplant population. In this project, we are testing whether these variants can help us understand if, how, and why certain patients will develop PTSD and other neuropsychiatric symptoms following solid organ transplantation. Need/Problem: Relative [...]

16 04, 2019

Transcranial Alternating Current Stimulation to Reduce Emotional Dysregulation in Veterans with Posttraumatic Stress Disorder | Frolich & Elbogen

Transcranial Alternating Current Stimulation to Reduce Emotional Dysregulation in Veterans with Posttraumatic Stress Disorder Need/Problem: Approximately one in five military veterans suffer from posttraumatic stress disorder (PTSD). Research documents PTSD is associated with poor post-deployment adjustment in military veterans, including increased risk of suicide, homelessness, violence, criminal arrest, and unemployment. As thousands of troops return home, there is an urgent need to develop effective treatment approaches that overcome barriers, are more feasible and less time-consuming to implement, and that veterans will prefer and actually use. Grant Summary: Transcranial Alternating Current Stimulation (tACS) provides a safe, non-invasive, easy-to-administer, and cutting-edge technology and procedure that applies weak electric currents to the scalp to modulate rhythmic brain activity patterns. The objective of this project is to establish the feasibility of the tACS treatment and collect pilot efficacy and electroencephalogram (EEG) biomarkers data [...]