CHAAMP

Identifying Novel Biological Profiles of Early Risk and Intervention for Mood Disorders in Adolescents: Mapping Stress-Responsive Changes in Electrocortical Indices in Adolescent Anhedonia 2024 Award: $74,802 Research shows that interpersonal stress increases risk for anhedonia, yet, not all adolescents who are exposed to interpersonal stress go on to experience anhedonia. Therefore, there is a critical need to understand which youth are most likely to experience anhedonia in the context of interpersonal stress. This study will integrate neural and physiological assessments to create novel biological profiles of stress responsivity and will examine whether these profiles can be used to predict adolescent anhedonia. Findings will serve as pilot data for future grants leveraging these biological profiles to improve early risk detection and treatment of adolescent anhedonia. Need/Problem: Anhedonia, the inability to experience or anticipate pleasure, is a core depression symptom that [...]

Identifying Modifiable Risk Factors Associated with Suicidality in Adolescents Following Acute Psychiatric Hospitalization 2024 Award: $78,000 Suicide is now the second-leading cause of death among adolescents, and some of the most vulnerable adolescents are those requiring acute mental health care. The rate of suicide in the 3 months following a psychiatric hospitalization is up to 100 times that of the general population, but despite this heightened risk, little is known about the ways in which modifiable factors of hospitalization impact suicidal thoughts and behaviors following discharge from the hospital. The present study will leverage the creation of UNC Youth Behavioral Health, a psychiatric facility for adolescents, to examine the ways in which underlying risk factors, course of hospitalization, and patient perceptions of hospitalization impact clinical outcomes in the three months following discharge among individuals who initially presented with suicidal [...]

Identifying Treatment Targets for Children of Mothers Who Experienced Sexual Violence 2023 Award: $199,000 Children whose caregivers have been exposed to trauma are at high risk for developing posttraumatic stress disorder (PTSD). In this project, we will examine the factors that increase risk for and the factors that protect against the onset of PTSD among offspring of trauma-exposed caregivers. Findings from this study will support future work to develop novel programs to prevent and treat youth PTSD. Need/Problem: Children whose caregivers are exposed to severe trauma are at high risk for developing posttraumatic stress disorder (PTSD). Most research focuses on the adult who was exposed to trauma, and scarce research has examined when and how caregiver PTSD may lead to offspring PTSD. Thus, there is limited understanding of how to prevent and intervene in the development of PTSD in [...]