Anxiety Disorders

//Anxiety Disorders
9 07, 2018

Deep Phenotyping of Behavioral Patterns Associated with Neuropsychiatric Disease | Kato | $162,000

Deep Phenotyping of Behavioral Patterns Associated with Neuropsychiatric DiseaseAward: $162,000Need/Problem: Why have advances in our understanding and treatment of mental illness lagged behind that of other biomedical conditions? To a large extent, this difference stems from the fundamental issue of diagnosis. For mental illness, diagnosis still relies exclusively on checklists of signs and symptoms, derived from observation by the clinician and self-reports from the patient. While this is critical, we can dramatically improve mental health diagnosis and treatment by fully integrating genetic, physiological, and neurocircuit information.  Much of these data rely heavily on preclinical experiments where studying genetic or neurocircuit underpinnings of mental illness. However, in preclinical models there is a clear lack of behavioral readouts that can be 1) associated with a particular psychiatric condition, and 2) clearly linked to back to molecular or circuit mechanisms.Grant Summary: Rodent behavioral [...]

9 07, 2018

Deconstructing Maternal Circuit Elements that Underlie Anxiety and Motivation | McHenry & Stuber | $40,000

Deconstructing Maternal Circuit Elements that Underlie Anxiety and Motivation Award: $40,000 Need/Problem: Approximately 13-20% of perinatal women are afflicted by psychiatric illnesses, such as postpartum depression. These conditions impair maternal health, compromise mother-infant interactions, and have adverse implications for the developing offspring. Grant Summary: Postpartum disorders may stem from perturbations in brain circuits that ordinarily act to promote maternal health and offspring care. However, a functional neural circuit level of understanding is poorly understood. For more effective treatments, it is necessary to gain a better understanding of the neural mechanisms that underlie both normal and pathological postpartum adaptations. The proposed research aims to establish a novel preclinical approach in a mouse model to elucidate the function of maternal circuit elements that affect infant care, anxiety, and motivation. Goals & Projected Outcomes: The proposed research aims to establish a novel [...]