Anxiety Disorders

//Anxiety Disorders
29 08, 2019

Dissecting the Neural Circuits of Hyperarousal States in Psychiatry | Dr. Jose Rodriguez-Romaguera | $200,000

Dissecting the Neural Circuits of Hyperarousal States in Psychiatry Award: 200,000 Anxiety is a complex state consisting of cognitive, emotional, and physiological components driven by a network across multiple brain regions. In this project, we plan on studying the neural circuits that regulate the hyperarousal state that often precedes the cognitive and emotional changes. Establishing the precise neural circuits involved in hyperarousal is critical to design novel therapeutic interventions for anxiety disorders. Need/Problem: Anxiety disorders are the most common mental illnesses in the United States, but we still poorly understand how specific neural circuits in the brain are affected during these disorders. Anxiety disorders are often characterized by an amplified arousal response to anxiogenic stimuli (hyperarousal). Grant Summary: Using pre-clinical mouse models we will use state-of-the-art microscopy techniques to visualize and record the activity of hundreds of individual neurons [...]

9 07, 2018

Deep Phenotyping of Behavioral Patterns Associated with Neuropsychiatric Disease | Kato | $162,000

Deep Phenotyping of Behavioral Patterns Associated with Neuropsychiatric Disease Award: $162,000 Need/Problem: Why have advances in our understanding and treatment of mental illness lagged behind that of other biomedical conditions? To a large extent, this difference stems from the fundamental issue of diagnosis. For mental illness, diagnosis still relies exclusively on checklists of signs and symptoms, derived from observation by the clinician and self-reports from the patient. While this is critical, we can dramatically improve mental health diagnosis and treatment by fully integrating genetic, physiological, and neurocircuit information.  Much of these data rely heavily on preclinical experiments where studying genetic or neurocircuit underpinnings of mental illness. However, in preclinical models there is a clear lack of behavioral readouts that can be 1) associated with a particular psychiatric condition, and 2) clearly linked to back to molecular or circuit mechanisms. [...]

9 07, 2018

Deconstructing Maternal Circuit Elements that Underlie Anxiety and Motivation | McHenry & Stuber | $40,000

Deconstructing Maternal Circuit Elements that Underlie Anxiety and Motivation Award: $40,000 Need/Problem: Approximately 13-20% of perinatal women are afflicted by psychiatric illnesses, such as postpartum depression. These conditions impair maternal health, compromise mother-infant interactions, and have adverse implications for the developing offspring. Grant Summary: Postpartum disorders may stem from perturbations in brain circuits that ordinarily act to promote maternal health and offspring care. However, a functional neural circuit level of understanding is poorly understood. For more effective treatments, it is necessary to gain a better understanding of the neural mechanisms that underlie both normal and pathological postpartum adaptations. The proposed research aims to establish a novel preclinical approach in a mouse model to elucidate the function of maternal circuit elements that affect infant care, anxiety, and motivation. Goals & Projected Outcomes: The proposed research aims to establish a novel [...]