dthompson

About Daphne Thompson

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So far Daphne Thompson has created 13 blog entries.
12 09, 2019

Genetic Risk Factors of Post-traumatic Stress Disorders in Solid Organ Transplant Recipients | Nash | $39,886

Genetic Risk Factors of Post-traumatic Stress Disorders in Solid Organ Transplant Recipients 2019 Award: $39,886 Medical post-traumatic stress disorder (PTSD) can be triggered by any number of surgical or medical interventions or critical illness. For example, patients awaiting a solid organ transplant face the ever-present threat of death if a matching organ does not become available; following transplantation, they live with the ongoing risk of organ rejection. Currently, we are unable to accurately predict who will suffer from PTSD or other neuropsychiatric symptoms following transplantation. However, certain genetic variants have been associated with PTSD in the general population, and could serve as susceptibility factors for the transplant population. In this project, we are testing whether these variants can help us understand if, how, and why certain patients will develop PTSD and other neuropsychiatric symptoms following solid organ transplantation. Need/Problem: [...]

5 09, 2019

Depression in the Pubertal Transition: Circadian Rhythms and Sleep Impairment as Mechanisms of Risk | Andersen | $37,920

Depression in the pubertal transition: Circadian rhythms and sleep impairment as mechanisms of risk 2020 Award: $37,920 Puberty is characterized by dramatic reproductive hormone instability, sleep and circadian rhythm disturbances, and an increased risk for depression, especially for girls. This study will examine the role of estrogen fluctuation in regulating sleep and circadian rhythms to understand risk for female-dominated adolescent depression. The pubertal transition is a critical developmental window offering a unique opportunity for identifying novel treatment targets and intervention efforts to diverge mental illness trajectories. Need/Problem: Adolescent girls have a three-fold greater risk for depression and a two-fold greater risk for sleep disorders compared with boys. The pubertal transition marks an abrupt divergence between the sexes in risk for depression and sleep disorders, implicating ovarian hormones (e.g., estrogen) as a common pathway of risk. With the prevalence of [...]

3 09, 2019

A Mechanistic Examination of Continuous-Cycle Oral Contraceptive Administration in Bulimia Nervosa | Baker | $46,942

A Mechanistic Examination of Continuous-Cycle Oral Contraceptive Administration in Bulimia Nervosa 2019 Award: $46,942 Binge eating fluctuates in a predictable pattern over the course of the menstrual cycle, but how reproductive hormones influence these changes remains unknown. Reproductive hormones could influence binge eating through their impact on response to reward. In this project, we will stabilize reproductive hormone fluctuation in women with binge eating using oral contraceptives in order to address how this stabilization influences binge eating and reward responsivity. Understanding how reproductive hormones act on binge eating could lead to new and more effective treatments. Need/Problem: There is a major disconnect between the negative consequences of eating disorders associated with binge eating and the availability of effective treatments. Female reproductive hormones such as estrogen and progesterone may play a role in the risk for binge eating, but it [...]