Dissection of Top-down Cortical Circuits Underlying Auditory Oddball Response, a Biomarker for Schizophrenia
2020 Award: $40,000
Hallucination, or “hearing voices” is one of the most prevalent symptoms of schizophrenia. In this project we will study how internally generated signals in the brains affect sensory processing. Findings in the simple mouse brains provide a first step toward the understanding of circuit mechanisms underlying broad perceptual symptoms in schizophrenic patients.
Need/Problem: Schizophrenia is a severe mental disorder that affects 1 in 100 individuals. Schizophrenic patients suffer from symptoms such as hallucinations (hearing voices), delusions, and disordered thinking.
Grant Summary: We will study how hallucination, or hearing internally generated sounds, occurs by investigating information processing in the neural circuits within the auditory cortex
Goals and Projected Outcomes: Insights into the interplay between sensory inputs and internally generated signals within the brain will help us understand how this balance is disturbed in schizophrenic patients. This knowledge will lead to the identification of potential therapeutic targets in future.