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So far Webpress has created 16 blog entries.
16 04, 2019

Identifying Susceptibility Loci for Tourette’s Syndrome in a Densely Affected Pedigree | Crowley

Identifying Susceptibility Loci for Tourette’s Syndrome in a Densely Affected Pedigree Need/Problem: Tourette’s Syndrome is a highly genetic condition with no effective treatment. We need to identify the genetic causes of this disorder in order to develop treatments. Grant Summary: This grant will take advantage of an extraordinary family from England that is both large and enriched for Tourette’s Syndrome in order to identify genes associated with Tourette’s Syndrome. Goals and Projected Outcomes: The goal of our study is to identify a gene or genes with altered function in this family, that predisposes individuals to develop Tourette’s Syndrome. James J. Crowley, PhD Grant Details: Tourette’s Syndrome (TS) is a poorly-understood neuropsychiatric illness characterized by recurrent, non-rhythmic tics. Diagnostic criteria for TS require age of onset <18 years, multiple motor and at least one vocal [...]

16 04, 2019

Transcranial Alternating Current Stimulation to Reduce Emotional Dysregulation in Veterans with Posttraumatic Stress Disorder | Frolich & Elbogen

Transcranial Alternating Current Stimulation to Reduce Emotional Dysregulation in Veterans with Posttraumatic Stress Disorder Need/Problem: Approximately one in five military veterans suffer from posttraumatic stress disorder (PTSD). Research documents PTSD is associated with poor post-deployment adjustment in military veterans, including increased risk of suicide, homelessness, violence, criminal arrest, and unemployment. As thousands of troops return home, there is an urgent need to develop effective treatment approaches that overcome barriers, are more feasible and less time-consuming to implement, and that veterans will prefer and actually use. Grant Summary: Transcranial Alternating Current Stimulation (tACS) provides a safe, non-invasive, easy-to-administer, and cutting-edge technology and procedure that applies weak electric currents to the scalp to modulate rhythmic brain activity patterns. The objective of this project is to establish the feasibility of the tACS treatment and collect pilot efficacy and electroencephalogram (EEG) biomarkers data [...]

16 04, 2019

Functional Development Abnormalities Associated with Genetic Risk of Bipolar during Infancy | Gao

Functional Development Abnormalities Associated with Genetic Risk of Bipolar during Infancy Bipolar disorder (BD) is a common psychiatric illness affecting ~1% to 2% of the population, which is characterized by affective symptoms varying between depression and mania. However, there is a profound lack of knowledge regarding the brain’s functional disruption mechanism underlying this disorder, especially during early childhood which is increasingly recognized as a critical time for this neurodevelopmental disorder. The use of neuroimaging technology to study infants with a genetic risk of BD (biological mother diagnosed with BD) provides a wonderful opportunity to investigate the earliest functional disruption mechanisms related to this disorder, which is critical for the derivation of new early diagnosis and intervention strategies. Dr. Wei Gao, Assistant Professor of Radiology and Biomedical Imaging Research Center (BRIC) at the University of North Carolina at Chapel Hill [...]

16 04, 2019

Early Brain Development via Deep Learning of DNA | Xia | $39,742

Early Brain Development via Deep Learning of DNA Award: $39,742 Need/Problem: Innovative methodological strategies are urgently needed to predict short-term and long-term cognitive outcome at early life so that early intervention can be implemented before any cognitive delay appears. Grant Summary: This grant is to develop deep convolutional neural networks to build a predictive model for early brain development through genome-wide DNA markers and developmental trajectories of cortical thickness and surface area. Goals and Projected Outcomes: The goal of this study is to develop the first deep learning procedure to predict early brain development using data from two well-characterized population cohorts studied from birth through 2 years of age. The success of this study will present strong proof that deep learning predicting neurodevelopment and cognitive functions is effective and powerful using genome-wide DNA markers, while none of other competing [...]

16 04, 2019

Reversing the pharmacological effects of cocaine by allopregnanolone | Robinson

Reversing the pharmacological effects of cocaine by allopregnanolone Need/Problem: There is a critical need for pharmacological therapeutics to treat stimulant addiction, for which there are no approved drugs. Grant Summary: This project will test whether allopregnanolone, a neurosteroid made in the brain, can counteract key effects of stimulants. Because of their few side effects, neurosteroids may be a novel and effective way to treat stimulant use disorder. Goals and Projected Outcomes: A growing body of basic and clinical evidence suggests that neurosteroids are promising therapeutic strategies for stimulant addiction, but critical pharmacological studies are lacking. This project aims to determine the ability of allopregnanolone to reverse the pharmacological effect of cocaine in an animal model. We hypothesize that allopregnanolone will reverse the effect of cocaine to enhance dopamine release and stimulate locomotion in awake rats. The resulting data will [...]

9 07, 2018

Next Generation Non-Invasive Brain Stimulation: A Novel Solution Enabled by Mobile Technology and Big Data | Frohlich | $200,000

Next Generation Non-Invasive Brain Stimulation: A Novel Solution Enabled by Mobile Technology and Big Data Award: $200,000 We know that applying very weak electric currents to the scalp, a process called transcranial current stimulation (TCS), can boost specific rhythmic activity patterns in the brain that are the foundation of cognition and behavior. Dr. Frohlich and his team proposed a mobile brain stimulator that would connect to central database, enabling researchers to study the clinical effects of TCS from a nationwide set of data. This could lead to a major breakthrough on how to treat mentally ill patients using methods that are safe, noninvasive, and effective. Flavio Frohlich, Ph.D. Need/Problem: Psychiatry urgently needs new treatment paradigms that are effective, safe, and affordable. Non-invasive brain stimulation such as transcranial current stimulation has the potential [...]