Alcohol Intoxication Mediated Through Medial Septal Circuitry
2017 Award: $39,210
In this research, researchers will use a novel mouse line to test the involvement of a specific neural circuit in brain in controlling alcohol intoxication. Selected cells in this circuit will be manipulated in an attempt to enhance or diminish the magnitude of intoxication. If the role of the circuit and cells can be shown, future work would expand the analysis of the neural connections to this circuit with the goal of inspiring novel avenues for therapeutic intervention in alcohol used disorders.
Need/Problem: A complete understanding of the brain mechanisms of alcohol intoxication has remained elusive. Research devoted to defining the neurocircuits of intoxication with state of the art neurobiological tools offers an opportunity to make advances in our understanding.
Grant Summary: This grant offers a novel approach to a long-standing mystery involving the circuits of the brain that control alcohol intoxication. The grant will employ a novel mouse line that will permit examinations of a hypothalamic/medial septal circuit in the actions of alcohol.
Goals & Projected Outcomes: We predict that excitation of neurons originating in the hypothalamus will mimic the effects of analeptic (anti-intoxicating) peptides, while inhibition of these neurons or blockade of the peptide receptors will mimic the effects of alcohol. Through this effort, we will define an important brain circuit in this neurobehavioral effect of alcohol.