Achieving Synergy with Multimodal Brain Stimulation: Electricity meets Magnetism

2016 Award: $156,613

Dr. Frohlich’s current exploration of noninvasive brain stimulation began with a Foundation grant in 2012, and continued in 2015 with an additional $200,000 award. The third phase of this project attempts to integrate electrical and magnetic stimulation—two methods often used separately—to target specific trouble spots and improve overall brain function.

Need/Problem: One effective treatment strategies for mental illnesses is to combine medications to achieve maximal therapeutic benefit. In contrast, despite the emergence of multiple, different forms of non-invasive brain stimulation for the treatment of mental illnesses, very little is known about the potential therapeutic synergy of different forms of non-invasive brain stimulation.

Grant Summary: This is the first study of its kind to investigate the targeted combination of transcranial magnetic stimulation and transcranial alternating current stimulation (tACS) for modulating brain rhythms.

Goals and Projected Outcomes: The goal of this study is to introduce a novel therapeutic approach which is based on leveraging network neuroscience to develop individualized treatment strategies.

Flavio Frohlich, PhD

Grant Details: By combining tACS and TMS, we will accelerate the development of innovative non-invasive brain stimulation that combines spatial and temporal targeting. This will allow us to capitalize on our leading role in the research community and help shape the future through continued competitiveness for large NIH grants.

The current study will be first conducted in health volunteer participants. The Carolina Canter for Neurostimulation under the direction of Dr. Frohlich is recruiting both patients and healthy participants for ongoing research projects. You can learn more at